Install the current PrusaSlicer from Prusa’s CORE One support page and add the exact printer through the configuration wizard. Select the installed nozzle diameter.
Choose the physical sheet and a filament preset that matches the spool. These choices affect first-layer temperature, cooling and enclosure behavior. Duplicate a system preset before tuning third-party material.
In Preview, check first-layer placement, bridge direction, supports and filament changes. Export BG-code or G-code through the supported USB or network route.
Keep one untouched baseline. When a custom profile fails, comparing it with Prusa’s current preset is faster than rebuilding settings from memory.
Before slicing, filament needs to be loaded correctly through the side sensor and Nextruder, which the CORE One filament loading guide covers in detail. Once a model is sliced, the guide to when supports are needed and how to remove them is useful for checking whether Preview’s support placement actually matches the geometry.